ECE2009 Poster Presentations Obesity and Metabolism (70 abstracts)
The effect of α-lipoic acid on myostatin and myosin heavy chain isoform profile of skeletal muscle of OLETF rats
Soon Jib Yoo 1 , Oak Kee Hong 1 , Do Man Kim 2 , Hyuk Sang Kwon 1 , Ho Young Son 1 , Sung Koo Kang 1 & Dong-Sun Kim 3
1The Catholic University of Korea, Seoul, Republic of Korea; 2Kandong Sacred Hospital, Seoul, Republic of Korea; 3Hangyang Univeristy, Seoul, Republic of Korea.
Aims: To investigate the mechanism of α-lipoic acid (ALA) on preventing diabetes, we evaluated the effect of ALA on growth regulation and composition of skeletal muscle.
Methods: OLETF and LETO rats, aged 24 weeks, were treated with or without ALA (100 mg/kg body weight/day in drinking water) and / or insulin (insulin glargine, 2 U/kg body weight/day; subcutaneous injection) for 8 weeks.
Results: The treatment of ALA with or without insulin reduce body weight significantly and save relatively larger amount of skeletal muscle mass from gastrocnemius compared with insulin-alone treated group and control group of OLETF rats. Myostatin gene expression in skeletal muscle was decreased in ALA-alone and insulin alone treated group compared with control group of OLETF and LETO rats. The isoform profile of MHC was significantly increased in MHC I, MHC IIa and MHC IId/x in ALA-alone treated group compared with the control group of OLETF rats.
Conclusion: The short-term treatment with ALA showed preventing weight gain, preserving skeletal muscle mass, decrement of myostatin gene expression and increment of both MHC I and IIa gene expression.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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