Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2009) 20 P455

ECE2009 Poster Presentations Obesity and Metabolism (70 abstracts)

Thyroid function tests, measures of adiposity and metabolic syndrome in apparently healthy euthyroid individuals

Katerina Saltiki 1, , Kimon Stamatelopoulos 3 , Paraskevi Voidonikola 3 , Emily Mantzou 1 , Christos Papamichael 3 & Maria Alevizaki 1,


1Endocrine Unit, Evgenidion Hospital, Athens University School of Medicine, Athens, Greece; 2Endocrine Unit, Department Medical Therapeutics, Alexandra Hospital, University School of Medicine, Athens, Greece; 3Vascular Laboratory, Department of Medical Therapeutics, Alexandra Hospital, University School of Medicine, Athens, Greece.


Objective: Thyroid function tests (TFTs) have been associated with obesity; however associations with the type of adiposity have not been examined. Ultrasound (U/S) was used to assess regional adiposity in euthyroid individuals. Associations of thyroid function with obesity parameters and presence of the metabolic syndrome (MS) were investigated.

Methods: Of 302 apparently healthy slightly overweight individuals (age 42.9±8.8, BMI 19.0–43.3, median 26.2 kg/m2, 180 women) were examined for indices of the metabolic syndrome (MS). Abdominal subcutaneous (SF) and pre-peritoneal (PF) fat layer was estimated by US. BMI, waist and hip circumference were recorded; TSH, T3, thyroid autoantibodies, insulin, glucose and lipid levels were measured.

Results: T3 levels were positively associated with PF (r=0.245, P=0.004), SF (r=0.189, P=0.019), BMI (r=0.257, P=0.0004), waist perimeter (r=0.324, P<0.0001) and waist-to-hip-ratio (r=0.363, P<0.0001). TSH levels correlated with SF (r=0.146, P=0.039). Higher TSH levels were associated with higher total cholesterol and LDL levels (P=0.008). HOMA-insulin-resistance-index and BMI were higher among individuals with TSH>2.5 mU/l compared to those with TSH≤2.5 mU/l, P=0.048). TFTs did not differ between those with MS and those without.

Conclusions: Increased subcutaneous and pre-peritoneal fat accumulation is associated with higher T3 levels in euthyroid slightly overweight individuals; this may represent a compensatory mechanism for the increased abdominal fat accumulation, as has been described in morbid obesity. The positive association of higher levels of TSH with SF may reflect associations with a mild hypothyroid state or possibly resistance to thyroid hormones as has previously been suggested.

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