Severe hypertriglyceridemia and triglyceride apheresis

Taner Bayraktaroglu; Mesut Ozkaya; Faruk Kutluturk; Adil Dogan Azezli; Yusuf Orhan

P437

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Endocrine Abstracts (2009) 20 P437

ECE2009 Poster Presentations Obesity and Metabolism (70 abstracts)

Severe hypertriglyceridemia and triglyceride apheresis

Taner Bayraktaroglu ^1, , Mesut Ozkaya ² , Faruk Kutluturk ³ , Adil Dogan Azezli ⁴ & Yusuf Orhan ⁴

Err

Author affiliations

¹Endocrinology and Metabolism, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey; ²Endocrinology and Metabolism, Medical Faculty, Sutcu Imam University, Kahramanmaras, Turkey; ³Endocrinology and Metabolism, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey; ⁴Endocrinology and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Introduction: Patients with extremely high triglyceride levels and associated lipemia are at high risk for acute pancreatitis. Hypertryiglycerideamia can be can be provoked when triglyceride levels exceed 1.000 mg/dl of acute pancreatitis.

Materials and method: In 7 patients with hyperlipidemic pancreatitis was evaluated. In addition to the standard therapy, they were treated with triglyceride apheresis. Acute pancreatitis was diagnosed based on the presence of clinical manifestations and consistent imaging finding on ultrasound and computed tomography in all patients. Plasma exchange was carried out using cascade filtration. Albumin, globulin, cholesterol, triglyceride, HDL, LDL, VLDL, lipase measured serially before and after each session of plasma exchange.

Results: The mean serum concentration of triglyceride after a single session of plasma exchange fell significantly 21 125±318–318±178 mg/dl.

Conclusion: In patients with triglyceride levels over 1000 mg/dl are at high risk for acute pancreatitis, plasma exchange can dramatically lower excessive triglyceride levels.