ECE2009 Poster Presentations Diabetes and Cardiovascular (103 abstracts)
The effect of creatinine clearance on the short-term outcome of neuropathic diabetic foot ulcers
Baris Akinci , Sena Yesil , Firat Bayraktar , Yasin Kucukyavas , Serkan Yener , Abdurrahman Comlekci & Sevinc Eraslan
Dokuz Eylul University, Izmir, Turkey.
Introduction: Reduced creatinine clearance is related to an increased risk of diabetic foot ulcer development. Wound healing has been reported to be worse in diabetic patients with impaired kidney functions than general diabetic population. This study aimed to investigate the effect of creatinine clearance on the short term outcome of neuropathic diabetic foot ulcers.
Materials and methods: Data from 147 neuropathic diabetic foot ulcer episodes were included in this observational study. Patients applied to Dokuz Eylul University Hospital between January 2003 and June 2008. Patients were excluded if they had limb ischemia. Diabetic nephropathy was investigated by 24 h urinary albumin excretion and serum creatinine levels. Creatinine clearance was calculated according to Cockcroft–Gault formula. Foot ulcers were followed up for 6 months to determine the outcome.
Results: Our short term follow-up revealed that neuropathic diabetic ulcers healed worse in patients with decreased creatinine clearance than in those who had normal creatinine clearance. Amputation rates were also found to be higher.
Conclusions: Our results suggest that creatinine clearance is an important factor affecting wound healing in patients with neuropathic diabetic foot ulcers.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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