ECE2009 Poster Presentations Diabetes and Cardiovascular (103 abstracts)
Evaluation of the severity of hepatic steatosis in type 2 diabetes
Leila Ben Salem Hachmi 1 , Leila Ben Farhat 2 , Ridha Waghlani 1 , Chiraz Bouzid 1 , Lotfi Hendaoui 2 & Claude Ben Slama 1
1National Institute of Nutrition, Tunis, Tunisia; 2Mongi Slim Hospital, Marsa, Tunis, Tunisia.
Objective: The objective of this study was to examine the factors influencing the severity of hepatic steatosis in type 2 diabetes.
Methods: Computed tomography imaging was used to assess hepatic fat content in 80 men and women with type 2 diabetes. Inclusion criteria included a confirmed diagnosis of type 2 diabetes (≥1 year of duration), without history of hepatic disease or daily consumption of alcohol drink. The ratio of liver to spleen attenuation (L/S ratio) was calculated. Patients with an L/S ratio ≤ 0.8 were considered to have severe fatty liver. We compared the 2 groups with moderate and severe steatosis.
Results: The prevalence of hepatic steatosis was 30% (24/80). Steatosis was severe in 29% (7/24) and moderate in 71% of patients. Mean alanine aminotransferase level and C reactive protein level are significantly higher in diabetes with severe steatosis (respectively 25.8±5.3 vs 20.4±6 P=0.04–12.6±15.1 vs 4.7±2.7 P=0.04). No significant difference was found concerning age, duration of diabetes, anthropometric parameters, HbA1C, triglycerides level, HDL cholesterol level and total cholesterol level between the 2 groups.
Conclusions: Type 2 diabetic patient with higher liver enzyme especially alanine aminotransferase and positive inflammatory parameters had a higher risk of severe steatosis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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