Endocrine Abstracts

Introduction: Type 2 diabetes is associated with lower total testosterone (TT) levels in cross – sectional studies. However, it is not known whether the defect is primary or secondary.

Method: We investigated the prevalence of hypogonadism in type 2 diabetes in men by measuring serum total testosterone (TT), SHBG, LH, FSH, prolactin (PRL) in 85 men with type 2 diabetes. Free testosterone (FT) was calculated by using TT and SHBG (CFT). Hypogonadism was defined as low CFT.

Results: The mean age was 51.4±5.87 years, Mean BMI was 26.6±3.6 kg/m², mean HbA1C was 8.815±2.1%, mean FBS was 197.7±74.5, mean TT was 460±20.5 ng/dl, mean CFT was 7.5±2.34 ng/dl, mean BT was 172.8±62.2 ng/dl, mean SHBG was 51.7±29.5. Of 36.6% of patients had hypogonadism. LH and FSH levels were not increased. There was a significant inverse correlation between BMI and TT (r=−0.367; P=0.001) but there wasn’t correlation between BMI with CFT. There was inverse correlation between SHBG and BMI (r=−0.25; P=0.02) and direct correlation between SHBG and age (r=0.4; P<0.001). There was inverse correlation between CFT and age (r=−0.2; P<0.05).

Conclusion: Hypogonadotropic hypogonadism is a common defect in type 2 diabetes that requires further assessment in terms of etiology of the defect and the possible consequences, complications, and treatment.