Endocrine Abstracts

Background: Currently, it is reported that statins may be useful in the treatment of DM foot ulceration¹. The aim of the study was to evaluate treatment with topical atorvastatin of the wounds of streptozotocine induced diabetic rats.

Materials and methods: Fifteen×fifteen mm sized wound were created in streptozotocin-induced rats. A total of twenty-eight diabetic rats were studied in 4 groups (n: 28). Any treatment was not administered in the first group. Second, third, fourth groups were performed 1:1 mixture of lanolin and vaseline; lanoline-vaseline plus 1% atorvastatine and lanoline-vaseline plus 5% atorvastatine, respectively. On seventh and fourteenth days, state of the wound healing was observed and the percent of wound healing was determined by being measured its size. The statistical analyses were carried out by Oneway Anova Tukey HSD test.

Results: On the fourteenth day, the rates of wound healing in first, second, third and fourth groups were 14, 40, 96.59 and 96.51%, respectively. Accordingly, in the multiple comparisons; the rates of wound healing were found to be significantly higher in the diabetic rat groups administering 1 and 5% atorvastatine compared with those administering mixture of lanolin-vaseline and untreatment (for comparison each one P<0.001).

Conclusion: Topical atorvastatine therapy may be useful on the wound healing in diabetic rats. Further clinic and experimental studies are needed to confirm detail these results.