ECE2009 Poster Presentations Diabetes and Cardiovascular (103 abstracts)
Inspiratory muscle strength is correlated with carnitine levels in type 2 diabetes
Fatih Kilicli 1, , Hatice Sebila Dokmetas 1, , Ferhan Candan 1, , Sefa Levent Ozsahin 1, , Serdal Korkmaz 1, , Elvan Amasyali 1, , Koray Fakioglu 1, , Fettah Acibucu 1, & Kürsat Dal 1,
1Department of Endocrinology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey; 2Department of Nephrology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey; 3Department of Chest Disease, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey; 4Department of Internal Medicine, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Background: Plasma carnitine insufficiency has been caused muscle weakness. Carnitine levels and pulmonary functions were lower in patients with diabetes.
Objective: To determine whether pulmonary functions are correlated with carnitine levels in patients with type 2 diabetes.
Setting: Internal medicine outpatient clinic of a university hospital.
Methods: Forty-nine patients with type 2 diabetes and 34 healthy controls were evaluated. Pulmonary functions and carnitine concentrations were studied.
Results: Carnitine levels were lower in type 2 diabetes group than control group, (52.56±12.38 and 78.96±10.66 ηmol/ml, respectively, P<0.0001). Pulmonary functions were not significantly differed between groups. Carnitine levels were not correlated with age, duration of diabetes, fasting blood glucose levels and, glycemic control (%HbA1c) in patients with type 2 diabetes. However, carnitine levels in patients group were correlated with % forced vital capacity (%FVC) (r=0.35, P=0.016), % forced expiratory volume in one second (%FEV1) (r=0.318, P=0.029), FEV1/FVC (r=0.302, P=0.039), inspiratory muscle strength (PImax) (r=0.407, P=0.023) and, %PImax (r=0.423, P=0.018). Multiple regression analysis including above parameters reveals %PImax was significantly associated with carnitine levels (β=0.431, P=0.019).
Conclusions: The present study suggests that low carnitine levels may be associated with lower %PImax in type 2 diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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