Endocrine Abstracts

Aim of the research: To study diabetes insipidus (DI) prevalence in the Republic of Uzbekistan (RUZ) according to National Register.

Materials and methods: Computerized database has developed which covers all 12 regions of RUZ and Republic of Karakalpakstan. Database includes 1822 patients with diabetes insipidus.

Results: According to the register there are 1822 patients with DI which occurs in men and women with similar rate – 968 (53.2%) and 854 (46.8%) respectively. The study of disease form has shown that in most cases central form of DI has seen – 896 (49.2%) patients, whereas idiopathic, renal, gestational and inherited forms have seen in 829 (45.5%), 87 (4.7%), 7 (0.4%) and 3 (0.2%) cases respectively. We revealed, that DI caused by stresses in 20.4% (372 patients) whereas neuroviral infection, hypothalamus and pituitary region tumors, heritage and pregnancy take place as a risk factors in 16.2% (295 patients), 4.8% (87 patients), 7 (0.4%) and 0.9% (16 patients) respectively. Idiopathic diabetes insipidus has diagnosed in overwhelming majority of patients – 48.9%. Among the ethiopathogenetic factors we should distinguish postoperative DI which occurs in 7 (0.4%) while postablative, after born trauma DI, autoimmune endocrinopathy, hypothalamus and sellar region tumors seen in 5 (0.3%), 22 (1.2%), 38 (2.1%) and 67 (3.7%) patients respectively. Manifestation features of DI were following: headaches in 905 (49%) whereas dizziness, dry mouth, polyuria, vision disturbances, dysmenorrhea, heartaches and fatigue in 698 (37.7%), 1331 (71.9%), 1325 (72.6%), 1279 (69.1%), 63 (3.4%), 11 (0.54%), 207 (11.2%) and 829 (44.8%) patients respectively. Also, we registered complications such as cardiovascular disease in 62 (3.4%) cases while dehydration, psychomotor excitement, coma, dysmenorrheal and renal disease in 60 (3.%), 47 (2.6%), 18 (0.1%), 67 (3.7%) and 164 (9.0%) cases respectively.

Conclusion: (1) Algorithm for the management of DI should include CT or MRI imaging of hypothalamus and pituitary region, (2) Register for DI allows studying epidemiology of the disorder as well as its evaluation and develop new treatment regimens, and improve prevention of DI in regional endocrine dispensaries and implement in everyday practice.