Endocrine Abstracts

Aim: To evaluate the frequency and morpho-histological characteristics of the colonic polyps (CP) in acromegaly patients (pts).

Materials and methods: We studied 53 pts (50 female, 3 men) aged 23–76 (median – 47) with active acromegaly. The mean disease duration was 10.7±4.3 years. Somatotropinoma was diagnosed in 51 pts and somatoprolactinoma in two. The activity of acromegal? was confirmed on the base of the clinical and hormonal data. Basal GH (median – 17.4 (6.7; 23.5) mU/l) and IGF-1 levels (according to the aged reference significances) were elevated. GH secretion in standard OGTT wasn’t suppressed (GH nadir >2.7 mU/l). Videocolonoscopy with biopsy of identified CP had been performed. Hematoxylin-eosin staining was used for histological samples.

Results: The hyperplastic CP were revealed in 16 from 53 (30.2%) cases. The solitary CP was diagnosed in 13 (81.35%), multiple – in 3 (18.7%) patients. CP size varies from 0.5 to 2.0 cm in diameter. The majority of CP was localized in c. sigmoideum (7 pts) and rectum (4 pts). Besides, CP were situated in c. transversum (1 pts), in cecum (1 pts), in c. ascendance, (1 pts), in c.descendence (1 pts), in rectosigmoid (1 pts), in ileocecal valve (1 pts). Pseudopolyps were revealed in two pts. Tubulo-villous adenoma was identified in one case. The colon cancer wasn’t diagnosed in our patients.

Conclusion: The prevalence of the colonic polyps achieves 30.2% among our patients with predominant localization in c. sigmoideum and rectum. The malignancy index of CP was zero.