Endocrine Abstracts

It is well known that subclinical hypothyroidism (SH) more often can be revealed in patients with heart ischemic disease (HID). Mild thyroid failure can cause decrease of catabolism at atherogenic lipoproteins, decrease of cardiac output and diastolic disfunction of left ventricle. Results of coronarography (CG) can reliable reflect the severity of coronary atherosclerosis. It seems to us very important to compare the results of CG with TSH level and lipoproteins in heart ischemic disease patients.

Methods: About 863 patients participated in our study. In all patient CG was performed by standart methodology of M. Judkins et al. We studied age, gender, body mass index (BMI) of patients, their smoking history, genetic predisposition, treatment with statins. Fasting blood samples were taken for measuring of lipoproteins and TSH level by reagents of third generation.

Results: There were 77.6% of men and 22.4% of women. Middle age was 56.85±0.29 years. To investigate relationship between TSH level and lipoproteins concentration we selected patients without statin therapy. In this group SH was revealed in 10.8% of patients (middle TSH was 7.66±1.11 IU/l). In patients with SH levels of cholesterol and low density lipoproteins were significantly higher than is euthyroid patients (P 0.004 and P 0.001). Multivessel damage of coronary vessels was revealed in 40.2% of patients and correlated with man gender, age, duration of smoking, genetic predisposition, hypertention, hyperlipidemia and TSH level more than 4 IU/l. The truncal damage of left coronary artery was in 38% of patients with SH and in 19.3% of euthyroid patients.