ea0020s14.1 | Thyroid | ECE2009
Costagliola Sabine
The thyrotropin receptor (TSHr) is a glycoprotein hormone receptor controlling the thyroid growth and the thyroid hormones production, upon stimulation by its natural ligand, the thyrotropin hormone (TSH). In some pathological situations, this receptor is activated in the absence of TSH, either by autoantibodies from patients with Graves disease (an autoimmune thyroid disease where the TSHr is targeted and activated by autoantibodies), or by activating mutations (as obse...