Endocrine Abstracts

PGC1 and RIP140 are key regulators of nuclear receptor signalling that control metabolic gene expression in adipose tissue, liver and muscle. PGC1 promotes whereas RIP140 represses the expression of a network of catabolic genes in adipose and muscle. Thus mice devoid of RIP140 accumulate less fat in adipose tissue and liver while mitochondrial biogenesis and respiration is increased in type 2 muscle fibres; as a consequence, the mice maintain their insulin sensitivity as they ...

Glucocorticoid hormones (GCs) remain the mainstay for the treatment of various inflammatory disorders, because of their great efficacy. The long-term usage of GCs is, however, overshadowed by the occurrence of debilitating side-effects, like osteoporosis, skin and muscle atrophy, diabetes and neurological disorders. GCs exert their functions through binding to the glucocorticoid receptor (GR), a transcription factor that regulates gene transcription in a positive or negative w...

Testosterone supplementation increases whole body and appendicular skeletal muscle mass, maximal voluntary muscle strength, and leg power. However, concerns about the long term risks of prostate and cardiovascular disorders in older men treated with testosterone have encouraged efforts to develop selective androgen receptor modulators (SARM) that increase skeletal muscle mass and improve physical function without the adverse effects on prostate and cardiovascular outcomes. The...

Thyroid hormone (T3) has been known for a long time to be required for brain development which activate TRα and TRβ nuclear receptors. In rodent models, histological defects are mainly observed in cerebellum. Whether T3 action during cerebellum development is due to direct regulation of gene transcription by liganded thyroid hormone receptors (mainly TRα) or also the indirect consequences of other defects and systemic disorders is currently unknown.<p class=...