Endocrine Abstracts

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Prostate cancer (PCa) patients are typically treated by androgen ablation therapies that ultimately fail when PCa enters in androgen-depletion independence (ADI), leading to metastasis and death. To develop better clinical treatments it is crucial to understand the mechanisms underlying progression towards ADI and metastasis. Using ChIP-seq technology, I will show how the forkhead factor FoxA1 precisely restricts the extension of the androgen receptor (AR) binding program main...

The absolute protein level of hormone receptors is a crucial determinant for cellular responsiveness towards hormone exposure. In that respect, it is important to note that, by recent progress in gene expression profiling techniques, a novel class of small non-coding RNAs has been discovered. These non-coding transcripts of approximately 21 nucleotides are called microRNAs (miRNAs) that downregulate protein levels in a cell by translational repression. Given the increasing and...