ea0020s3.2 | Genetics in neuroendocrinology | ECE2009
Clark Adrian
, Hughes Claire
, Metherell Louise
ACTH insensitivity or familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder first described in 1959. We demonstrated in 1993 that about 25% of affected patients have nonsense or (more commonly) missense mutations in the ACTH receptor (melanocoprtin 2 receptor, MC2R). Functional analysis of these mutations had been especially difficult until our discovery in 2005 that the receptor requires an essential accessory factor the melanocortin 2 recepto...