ea0020gh1 | The Geoffrey Harris Prize Lecture | ECE2009
Gustafsson J-A
Estrogen signaling is mediated by two isoforms of the soluble estrogen receptor (ER), ERα and ERβ. In general, ERα and ERβ appear to have distinct, specific actions, sometimes of antagonistic nature (yin/yang). ERβ is widely distributed and studies on mice with deleted ERβ show phenotypic alterations in many tissues, indicating that ERβ has essential roles in several physiological contexts. In the CNS, ERβ is essential for development of...