Endocrine Abstracts

Background: High association of concomitant thyroid and parathyroid disorders has been reported. The aim of this study was to determine the prevalence and characteristics of thyroid disorders associated with primary hyperparathyroidism (PHPT) in Turkey, a country with mild iodine deficinency.

Material and method: We retrospectively reviewed the records of patients diagnosed with PHPT between 1980 and 2007 at our clinic and analyzed the data related to thyroid.

Results: There were 166 cases available. One hundred and thirty two patients had data regarding thyroid status. (Age 50.8±12.6, F/M; 109/23). One hundred and twelve (67.5%), 1 (0.6%), 7 (4.2%) were euthyroid, hypothyroid and hyperthyroid respectively. Five (3%) and 7 (4.2%) had subclinical hypothyroidism and subclinical hyperthyroidism respectively. Ultrasound was available on 104 of 132 patients. Among these who had autoantibodies and fine needle aspiration biopsy; 36 (34.6%) had multinodular goiter, 12 (11.5%) had solitary nodule, 5 (4.8%) had Graves’ Disease, 10 (9.1%) had Hashimoto’s Disease, 2 (1.9%) had toxic adenoma and 6 (5.8%) had Plummer’s disease. Eight patients (7.7%) had thyroid malignancy. (7 papillary, 1 follicular carcinoma). MEN was not detected. Rest has normal morphology. Among 124 (74.6%) out of 166 patients had thyroid pathology either related to function or morphology.

Conclusion: We report here a 74.6% prevalence of coexisting incidental thyroid disease in PHPT patients. Our results suggest that it is necessary to evaluate thyroid before parathyroid surgery for PHPT particularly in areas with iodine deficiency.