Endocrine Abstracts

Introduction: The influence of demographic and clinical factors on the outcome of ¹³¹I therapy in hyperthyroid patients has been examined, based on a retrospective evaluation of results obtained in patients, submitted to ¹³¹I treatment. The goal of the study was an analysis of factors, including the age and sex of patients, disease duration time, as well the hormonal status before ¹³¹I application, which could have influenced the effects of therapy with radioiodine ¹³¹I.

Patients, materials and methods: The study involved five hundred (500) randomly selected patients with hyperthyroidism, treated with ¹³¹I radioiodine. The following three (3) groups were defined: Group 1 – patients with multinodular goitre – n=200; Group 2 – patients with a single autonomous nodule of the thyroid – n=100; Group 3 – patients with Graves’ disease – n=200. The local ethics committee approved the study.

Results and conclusions: The obtained results indicate that the efficacy of therapy with ¹³¹I, applied in patients with multinodular goitre, single thyroid nodule and Graves’ disease, does not depend on either patient sex or patient age. The length of antithyroid treatment before ¹³¹I therapy onset does not appear to have any effect on the therapy outcome, while the baseline TSH concentration seems to be significant only in case of Graves’ disease.