ECE2009 Poster Presentations Reproduction (50 abstracts)
Periodontal disease in polycystic ovary syndrome
Erhan Dursun 1 , Guliz Guncu 1 , Nese Cinar 2 , Ayla Harmanci 2 , Murat Ozbek 3 , Erdem Karabulut 4 , Tolga F Tozum 1 , Kamer Kilinc 4 , F Alev Akalin 1 & Bulent O Yildiz 2
1Department of Periodontology, Hacettepe University School of Dentistry, Ankara, Turkey; 2Endocrinology and Metabolism Unit, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey; 3Department of Oral Diagnosis and Radiology, Hacettepe University School of Dentistry, Ankara, Turkey; 4Department of Biostatistics, Hacettepe University School of Medicine, Ankara, Turkey; 5Department of Biochemistry, Hacettepe University School of Medicine, Ankara, Turkey.
Background: Periodontal disease (diseases of the tissues around teeth) and polycystic ovary syndrome (PCOS) are common disorders in women with a significant public health impact. Both disorders appear to be associated with diabetes and cardiometabolic risk. There are no published data regarding periodontal disease in PCOS.
Objective: To determine periodontal status in women with PCOS compared to healthy women.
Methods: We studied 25 non-obese PCOS patients with normal glucose tolerance (age: 22.5±3.6 y, BMI: 23.2±3.1 kg/m2) and 12 age- and BMI-matched healthy controls. All of the participants were non-smokers. Periodontal clinical parameters including probing depths (PD), clinical attachment levels (CAL), gingival index (GI), bleeding on probing (BOP) and plaque index (PI) were recorded during early follicular phase of the menstrual cycle. As a potential contributor to periodontal status and PCOS, selected oxidative stress biomarkers were also assessed. Nitric oxide in terms of nitrite and nitrate were measured in both gingival cervicular fluid (GCF) and blood samples while myeloperoxidase levels measured in GCF only.
Results: PD, CAL, GI, BOP and PI were significantly higher in PCOS patients compared to controls (P<0.01 for all). GCF myeloperoxidase levels were also significantly higher in the PCOS group (P<0.05). There was a non-significant trend of an increase of GCF nitrite and nitrate levels in PCOS group; whereas serum nitrite and nitrate levels were similar between the PCOS and control groups.
Conclusion: Our results suggest that the susceptibility for periodontal disease is significantly increased in patients with PCOS compared to age- and BMI-matched healthy young women, and that local/periodontal oxidant status appears to be affected in PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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