Endocrine Abstracts

Background: Classical risk factors are not capable to explain all the cardiovascular events and new markers are being evaluated to predict events.

Aims: We examined the effects of a single session of submaximal exercise (cardiopulmonary exercise cycle ergometer test) on atherogenic lipids in obese subjects focusing on inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP), and oxidized low-density-lipoproteins (oxLDL) as a marker of oxidative stress.

Methods: The study group consisted 30 obese subjects (age: 48±3.8, f/m: 20/10, body mass index (kg/m²) 31.55±2.3), participated in a bicycle ergometer 45 min submaximal exercise test. Blood samples were drawn immediately before, 30 minutes and 1 h after completion of the exercise. We determinate the follows lipids profiles: oxidized LDL (oxLDL), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). High-sensitivity C-reactive protein (hs-CRP) served as an inflammatory biomarker.

Results: Post-exercise levels of oxLDL (91.50±12.25 vs 96.83±11.20 UI/l P=0.01), and LDL-C (4.15±0.62 vs 4.19±0.63 mmol/l), compared to pre-exercise levels were increased, whereas 1 h after exercise, levels of oxLDL (91.50±12.25 vs 82.2069±11.29 UI/l, P=0.001), LDL-C (4.15±0.62 vs 3.86±0.62 mmol/l, P=0.05), and hs-CRP (2.42±0.98 vs 1.66±0.83 mg/ml, P=0.001) significantly decreased. There were no significant TG and HDL-C changes. Post-exercise levels of hs-CRP were negative correlated with body mass index (r=−0.388, P=0.05).

Conclusions: We found that a single session of submaximal exercise in obese subjects favorably modulates inflammatory mediators known to contribute in atherogenesis mechanisms.

Funding: Investigator is supported by grants from the CHC Dr Dragisa Misovic.