Endocrine Abstracts

The present study was carried out to investigate the possible toxic effects of different doses of a two component of Nurelle D 220 EC (200 g of chlorpyriphos-ethyl and 20 g cypermethrin per 1 l) on blood hematology, testosterone and thyroxin levels, and semen quality of male rats. As well as histological examination of testis and epididymis. The investigation covered four groups of 8 rats each: three experimental groups and one served as control. The mixture liquid was given t...

Objective: An adequate thyroid function during pregnancy is essential for the normal brain development of the foetus, and some organochlorine compounds (OCs) can interfere with the thyroid system. The objective of the present study was to evaluate the association between exposure to some OCs and thyroid function in pregnant women from two different areas in Spain, as well as to investigate the potential confounding effect of iodine intake.Methods: Thyroi...

Objective: Stress has been linked to several diseases. In the course of stress; blood sugar. cortisol and catecholamine levels increase. Visceral hypersensitivity will increase due to catecholaminergic discharges leading to an over-induction of the intrapancreatic secretion. A chronically stress has a role in the induction of insulin resistance in different tissues and pancreas begins to release excessive insulin causing burned out pancreas. For this reason, it becomes insulin...

Aim: Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids to normal level is very important. The effect of oral administration of Vaccinium myrtillus (VM) on serum glucose and lipids in diabetic rats was investigated.Material and methods: Female Wistar rats were divided into 4 groups, i.e. control, VM-treated control, diabetic, and VM-treated diabetic groups. The treatment groups received oral administration of plant-mixed p...

Aim: Neuropathy is one of the potentially serious late complications of diabetes that occurs in certain tissues as a consequence of long-term hyperglycemia. Oxidative stress has been implicated to play an important role in the pathogenesis of diabetic neuropathy. In the present study, we have investigated the effect of silymarin, as a potent free radical scavenger in streptozotocin (STZ)-induced diabetic neuropathy in rats.Material and methods: The rats ...

Introduction: Hypogonadism in men is the increasing problem of the present medicine, specially concerning patients suffering from chronic diseases, e.g. diabetes, chronic kidney diseases. However, there are no enough data referring to haemodialysed patients and correlation with adequacy of dialysis was not found.Aim: The aim of the study was to assess the gonadal status of male patients receiving dialysis in our ward with reference to parameters of adequ...

Background and aim: Pyrethroids are commonly used as insecticides for both household and agricultural purposes, and recently have been shown to have detrimental effects on endocrine system. Permethrin is a type I pyrethroid which is used widely in Iran. In the present study the effects of permethrin on sexual behaviour and plasma level of PG (pituitary–gonadal) hormones of adult male mice were investigated.Material and methods: Mice received daily I...

The hyperprolactinemic disorder is a syndrome of prolactin hypersecretion. The syndrome is more prevalent in women than in men, but lately accidence of the syndrome disease tends to increase in men. Hyperprolactinemic disorder mostly affects men at the age range 40–59 years. Patients at the physician’s consultation have following complaints: erectile dysfunction, infertility, libido reduction, rarely gynecomastia.Sixteen patients were examined ...

Type 1 diabetes (T1D) is a complex autoimmune disease. Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population. DNA from 120 patients with T1D and 96 control individuals were genotyped for CTLA4 exon 1 polymorphism by polymerase chain reaction (PCR) amplification-restriction enzyme analysis and PCR amplification that used sequence-specif...

Introduction: Underdiagnosis and delayed diagnosis of Klinefelter syndrome (KS) is a major problem. KS is revealed only in 25% of the expected amount of patients. Early diagnosis facilitates prevention of the long-term consequences of hypogonadism and permits to begin testosterone-replacement therapy opportunely. The ‘prototypic’ patient with KS has traditionally been described as tall, thin, with long hips, narrow shoulders, having gynecomastia, small testes, sparse...