Endocrine Abstracts

Aims: In this study, we examined the relationships between levels of adipocytokines and traditional and non-traditional cardiovascular risk markers in patients with type 2 diabetes mellitus (T2DM).

Methods: Serum leptin, resistin, adiponectin, visfatin, high sensitive C-reactive protein (hsCRP), homocystein, asymetric dimethylarginine (ADMA), fasting glucose, insulin, glycated haemoglobin (HbA₁C) and full lipid and lipoprotein profile, systolic blood pressure (SBP), diastolic blood pressure (DBP) were determined in type 2 diabetic patients. Results were compared with those control subjects.

Results: The levels of serum adiponectin were decreased and resistin, leptin and visfatin levels were increased in diabetic patients compared to that in controls (P<0.001, in each). Adiponectin showed significant negative correlations with body mass index (BMI), insulin, HbA₁C, triglyceride, homeostasis model assessment of insulin resistance (HOMA-IR), hsCRP, ADMA, visfatin, resistin, leptin and possitive correlations with high-density lipoprotein-cholesterol (HDL) and apolipoprotein A1 (Apo A1). Resistin showed significant possitive correlations with insulin, HOMA-IR, hsCRP, homocystein, visfatin, leptin and negative correlations with adiponectin, HDL, and Apo A1. Leptin showed significant positive correlations with age, BMI, HOMA-IR, homocystein, triglyceride, insulin, visfatin, resistin, SBP, DBP.and negative correlations with HDL and adiponectin. Visfatin showed significant possitive correlations with age, insulin, HOMA-IR, hsCRP, resistin, leptin, and negative correlations with adiponectin, HDL and Apo A1.

Conclusion: These findings may suggest that levels of serum leptin, resistin, adiponectin, visfatin are associated with obesity, insulin resistance and cardiovascular risk markers in T2DM patients. Therefore these adipocytokines may be useful indicators for assessing the cardiovascular disease risk in patients with type 2 DM.

This study supported by Eskişehir Osmangazi University research fun (2006-11031).