ECE2009 Poster Presentations Diabetes and Cardiovascular (103 abstracts)
HLA DQB1 and HLA DQA1 genotypes prevalence in children and adolescence with new-onset diabetes type 1 in the lower Silesia region
Teresa Zak , Malgorzata Malodobra , Agnieszka Zubkiewicz & Anna Noczynska
Department of Endocrinology and Diabetology for Children and Adolescents, Wroclaw, Poland.
The first degree relatives of patients with diabetes type 1 have increased genetic risk of developing clinical disease. In the population of Polish diabetic subjects the most frequent alleles are HLA- DRB1*04, DRB1*03, DQA1 and DQB1. The ‘high-risk genotype’ may differ among populations.
The aim of this paper was to analyze prevalence of genetic risk factors in patients with new-onset diabetes in Lower Silesia and to compare the data with Polish population and Caucasian one.
The study involved 58 patients with new-onset diabetes type 1, 34 boys and 24 girls, 11 months to 18 years of age, admitted to the Department of Endocrinology and Diabetology for Children and Adolescence, Wroclaw Medical University, from June 2007 to May 2008. HLA DQB1 and HLA DQA1 genes were analyzed: SNP polymorphism of HLA DR gene locus was assessed using ABI 3130 gene analyzer with GENEscan software.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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