Endocrine Abstracts

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are important neuropeptides that are structurally related. They have been found to exert many physiological and pathophysiological effects through the activation of three specific receptors: PAC1R, VPAC1R, and VPAC2R. In tetrapods, PACAP and VIP are potent agonists to VPAC2R. In teleosts, we have previously identified a PHIR in goldfish which shares high level of sequence similarity ...

Orchidectomy performed during breeding season (winter) in the adult male gerbil, Gerbillus tarabuli, live trapped in its natural biotope in Béni Abbès area (30°7 N., 2°10 W.) in algerian Sahara desert, induced 50 days later, important weight, histological and hormonal changes on the adrenal gland.Adrenal weight increases by 69.7% (P=0.06) and adrenal cortex height by 48.6% (P=0.00) with hypertrophy of reticularis ...

In recent decades intensive studies on the glycoprotein-hormone receptors (GPHRs) and their respective hormones have provided a number of molecular insights into the relationship between the structure and function of these proteins. This knowledge includes an understanding of hormone binding, of naturally occurring mutations nad mechanisms of signal transduction and G-protein binding processes.Together with the relaxin family peptide receptors (RxFP) the...

Aim of the research: To study diabetes insipidus (DI) prevalence in the Republic of Uzbekistan (RUZ) according to National Register.Materials and methods: Computerized database has developed which covers all 12 regions of RUZ and Republic of Karakalpakstan. Database includes 1822 patients with diabetes insipidus.Results: According to the register there are 1822 patients with DI which occurs in men and women with similar rate –...

Pregnancy is characterized by profound changes in woman’s hormonal and metabolic status. Cortisol has been postulated to play a central role in the physiological changes associated with pregnancy. The extends of this effect in the three stages of pregnancy remain to be fully investigated. The current study investigates the level of serum cortisol in the three stages of pregnancy and correlates this with reproductive hormones and electrolyte balance. These changes were fur...