Endocrine Abstracts

The PI3 kinase family plays an important role in controlling many critical biological processes. There is accumulating evidence that PI3 kinase signalling is involving in a range of diseases and that PI3 kinase inhibitors could offer considerable therapeutic potential. This presentation will focus on the discovery and development of PI3 kinase inhibitors for cancer treatment. The availability of potent and selective PI3 kinase inhibitors is particularly timely given the accumulation of evidence for extensive genetic deregulation of the PI3 kinase signal transduction pathway, including activating mutations in P110α and loss of PTEN. Recent progress and future challenges will be discussed.