Endocrine Abstracts

Obesity and excess adiposity may occur following treatment for childhood acute lymphoblastic leukaemia (ALL) even in those not administered cranial irradiation. Prior glucocorticoid treatment may be contributory as glucocorticoids have direct effects on fat mass (FM) and adipocytes. From 1997 to 2003 children treated for ALL in the UK were randomised to receive either prednisolone or dexamethasone.Objectives: In survivors of childhood ALL not treated wit...

Aim: There is emerging evidence that survivors of BMT not only suffer long term endocrine sequelae, but also have an increased risk of cardiovascular disease. The UKCCSG guidelines suggest that BMT survivors should be monitored for cardiac and lung toxicities of previous treatments using cardiac ECHOs and pulmonary function tests (PFTs). We aimed to examine body composition, aerobic fitness, ECHOs and PFTs in adolescent and young adult survivors on GHTx....

Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. Given dramatic improvements in survival rate (>80%), long term quality of life is of rising concern. Skeletal complications including osteonecrosis (ON) are being reported more frequently, affecting up to 38% of children treated for ALL though the pathogenesis is unclear.The purpose of this study is to examine possible mechanisms causing ON. We hypothesize that polychemotherapy ...

Background: Children receiving chemotherapy for ALL may be susceptible to fractures and avascular necrosis (AVN).Aim: To determine the incidence and risk factors for bone-related morbidity in children on ALL chemotherapy.Patients and methods: The medical records of all (n, 186, male: 122) children presenting with ALL between 1997 and 2007 and treated with ALL97/01or UKALL 2003 at one centre were studied. Bone morbidity was d...