Endocrine Abstracts

The aim of the study was the analysis of dependencies between sex hormones and metabolic syndrome.

Forty-five women with metabolic syndrome and 49 healthy women were examined.

The diagnostic criteria of metabolic syndrome: waistline ≥80 cm, waistline/hips index WHI≥0.85 and also having 1 or 2 cardiovascular risk factors: glucose≥100 mg%, RR≥130/80, HDL< 50mg% and TG≥150 mg%.

The levels of estradiol (E₂), testosterone (T), dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding globulin (SHBG) were measured. Free testosterone index (FTI), free estradiol index (FE₂I) and free testosterone (FT) were determined by means of a calculation method.

A significant difference between the group with metabolic syndrome (FTI-5.13±3.72, FE₂I-517.28±539.69, SHBG-48.49±32.18 nmol/l) and the control group (FTI-3.04±1.65, FE₂I-281.72±313.6, CRP-1.49±1.38 mg/dl, SHBG-61.28±30.89 nmol/l) concerned FTI(P<0.01), FE₂I (P<0.05), SHBG (P<0.05).

There was a significant correlation of waistline with SHBG (r=−0.274), with FTI (r=0.324) and with FE₂I (r=0.248) and WHI with SHBG (r=−0.239), with FTI (r=0.302), with FE₂I (r=0.210) in women with metabolic syndrome.

The pathogenesis of metabolic syndrome in menopausal women is connected with bioavailability of sex hormones and binding proteins.