Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 16 P184

ECE2008 Poster Presentations Diabetes and cardiovascular diseases (90 abstracts)

Effects of micronutrients supplementation on lipid peroxidation in Type 2 diabetes

Maryamsadat Farvid 1 , Mahmoud DJalali 2 & Feraydoun Siassi 2


1Faculty of Nutrition Sciences and Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of Iran; 2Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.


Objective: The present study designed to assess the effect of Mg+Zn, vitamin C+E, and combination of these micronutrients on glycemic control, lipid profile and lipid peroxidation in type 2 diabetic patients.

Materials and methods: In a randomized, double-blind, placebo controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months; group M: 200 mg magnesium and 30 mg zinc (n=16), group V: 200 mg vitamin C and 150 mg vitamin E (n=18), group MV: minerals plus vitamins (n=17), group P: placebo (n=18).

Results: Results indicate that after 3 months of supplementation mean serum levels of HDL-C and apolipoprotein A1 increased significantly in the MV group by 24% (50.4±19.3 vs 40.6±10.8 mg/dl) and 9% (170±34 vs 156±24 mg/dl), respectively (P<0.01). Levels of fasting serum glucose decreased in MV group (P<0.05). Malondialdehyde concentrations decreased significantly in the M and MV groups (P<0.05 and P<0.01, respectively). Arylesterase activity increased significantly in the M group (91±24 vs 87±24, P<0.05) There were no significant changes in the levels of these parameters in the other groups. HbA1, fructosamine, insulin and HOMA score and serum levels of total cholesterol, LDL-C, triglyceride, apolipoprotein B and paraoxonase activities were not altered after supplementation in all 4 groups.

Conclusion: It is concluded that since co-supplementation of Mg, Zn, vitamin C and E significantly increases HDL-C and apolipoprotein A1 and improves fasting serum glucose and lipid proxidation, supplementation of these micronutrients should be recommended for the type 2 diabetic patients based on their daily requirements.

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