Endocrine Abstracts

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It is well established that nuclear retinoic acid (RA) receptors (RARα, RARβ and RARγ) activate gene expression through a complex and evergrowing network of dynamic interactions with coregulatory protein complexes, which are coordinated by the ligand.Adding more complexity to this scenario, we demonstrated that RARs are also targets for phosphorylation processes, which govern their transcriptional activity in cooperation with the ligand. I...

Post-translational modifications of histones such as methylation, acetylation, and phoshorylation regulate chromatin structure and gene expression. However, phosphorylation of histone H3 at threonine 11 (H3T11ph) has not been linked to transcriptional regulation. Here we show that protein kinase C-related kinase 1 (PRK1) phosphorylates H3T11 upon ligand-dependent recruitment to androgen receptor (AR) target genes. PRK1 is pivotal to AR function since PRK1 knockdown by RNAi or ...

Adaptation of oxidative metabolism is essential for meeting different energy demands in different tissues, or altered energy demands in response to stressors, such as exposure to cold. The orphan nuclear receptor ERRα (estrogen-related receptor alpha) is implicated in the regulation of energy metabolism. ERRα expression is high in tissues with high oxidative capacity and increased at physiologic states of increased energy demand. Moreover, ERRα activity and expr...