Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 16 P635

ECE2008 Poster Presentations Reproduction (48 abstracts)

Effects of Tadalafil on nocturnal penile tumescence and rigidity in normal men: randomized, placebo-controlled, crossover study

Antonio Raffaele Michele Granata , Bruno Madeo , Giovanni De Mola , Alessandro Guidi , Valeria Pugni , Vincenzo Rochira & Cesare Carani


Chair of Endocrinology, Integrated Department of Medicine, Endocrinology, Metabolism and Geriatrics, University of Modena and Reggio Emilia, Modena, Italy.


Subjects and methods: We performed nocturnal penile tumescence and rigidity monitoring (NPTRM) in order to study the effects of Tadalafil on sleep-related erections in 23 adult healthy men (age: 34.27±8.48 years). The subjects were randomly administered Tadalafil, 10 mg tablet, the 1st (N1) or the 2nd (N2) night (Group A and B respectively) of 3 consecutive nights of erections’ monitoring. In Group A the 3rd night monitoring was regarded as control (N-ctr); in Group B the 1st night. Tadalafil was administered 2 h after last food assumption before bedtime. The NPTRM parameters analyzed were: number of valid erections, total duration of rigidity ≥60% and ≥70% maximum rigidity, maximum increase of tumescence and total duration of increase of tumescence ≥30 mm.

Results: Number of valid erections (p N-ctr vs N1: <0.01; p N-ctr vs N2: 0.01), total duration of rigidity ≥70% (p N-ctr vs N1: 0.03; p N-ctr vs N2: 0.05) and maximum increase of tumescence (p N-ctr vs N1: 0.03; p N-ctr vs N2: 0.03) were significantly higher in nights 1 and 2 after Tadalafil than in control night; no differences occurred between the 2 nights after Tadalafil. Total duration of rigidity ≥60% (p N-ctr vs N1: 0.03; p N-ctr vs N2: ns) and total duration of increase of tumescence ≥30 mm (p N-ctr vs N1: <0.01; p N-ctr vs N2: 0.06) showed higher values only in night 1 after Tadalafil than in control night. In parenthesis values are mean±S.E.M.

Conclusion: Our data suggest that Tadalafil is efficacious in improving sleep-related erections. Furthermore in normal men Tadalafil improved NPTRM also in the second night after 24 h from the drug assumption.

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