Endocrine Abstracts

The goal of this study was to determine whether galanin affects the mean plasma concentrations of metabolic parameters such as thyroxine (T4), triiodothyronine (T3), growth hormone (GH), insulin, glucagon, glucose, fatty acid and urea in the camels fed different energy content in diets. Twenty four camels were randomly divided into three main groups. Animals of all groups were fed either 25, 50 or 100% energy content in diet for 30 days. After 30 days, camels were received daily single injections of either 1 or 2 ug galanin/kg BW into their jugular vein for 5 days. Blood samples were collected daily from jugular vein of all animals on day 4 before injections until 4 days after the last injections of galanin. Samples were assayed for plasma T3, T4, GH, insulin and glucagons concentrations by double-antibody RIA. Glucose, fatty acid and urea concentrations were also measured. Twenty five percent energy content in diet for thirty days significantly (P<0.01) increased the mean plasma concentrations of GH, glucagons and fatty acid of the animals and this increased concentrations significantly (P<0.01) elevated by injection of 1 and 2 ug galanin/kg BW. Mean plasma concentrations of insulin and glucose were significantly (P<0.01) lower in those animals fed twenty five percent energy content in diet, but this concentrations did not change by injections of 1 and 2 ug galanin/kg BW. Lower energy dietary intake and injections of 1 and 2 ug galanin/kg BW did not change the mean plasma concentrations of the T3 and T4 and urea in the animals of all groups. The result of these experiment indicated that galanin may positively affects mean plasma concentrations of GH, glucagon and fatty acid in camel only with negative energy balance along with severe body weight lost.