SFEBES2008 Poster Presentations Diabetes, metabolism and cardiovascular (51 abstracts)
Independent effects of insulin resistance and high molecular weight adiponectin on HDL cholesterol in polycystic ovarian syndrome
Niamh Phelan 1 , Annalouise O’Connor 2 , Tommy Kway Tun 1 , Neuman Correia 1 , Helen Roche 2 , Gerard Boran 1 & James Gibney 3
1Department of Endocrinology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland; 2Nutrigenomics Research Group, The Conway Institute, University College Dublin, Ireland; 3Department of Chemical Pathology, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland.
There is an increase in cardiovascular risk factors in polycystic ovarian syndrome (PCOS) compared with BMI matched controls. Almost all women with PCOS are insulin resistant and increased cardiovascular risk is commonly attributed to insulin resistance (IR). However, it is unclear if cardiovascular risk differs in women with PCOS compared to equally insulin resistant women. We performed a case–control study (n=56 pairs) of women with PCOS (NIH criteria) compared to women matched for age, body composition, nutritional factors and IR (HOMA, Quicki and Avignon insulin sensitivity index). Glucose and insulin were measured during an OGTT and plasma sampling was carried out for hormones, lipids, fatty acid composition, NEFA, adiponectin, homocystine and fibrinogen. Percent Body fat was estimated using bioimpedence. Total adiponectin did not differ between the groups, but high molecular weight (HMW) adiponectin (which is testosterone dependent) was lower than control subjects. HMW adiponectin proved the strongest predictor of HDL-C which also correlated with IR.
In conclusion, women with PCOS have lower HMW adiponectin and HDL-C than women matched for age, body composition and insulin resistance. These differences may reflect hyperandrogenaeia in PCOS with HMW adiponectin as a potential link between hyperandrogenaemia and low HDL-C.
| PCOS | Control | P-value (paired t-test) | |
| Age (years) | 30.1±5.3 | 31.0±5.4 | NS |
| BMI (kg/m2) | 32±7 | 32±6 | NS |
| HOMA-IR | 2.87±2.26 | 2.77±1.97 | NS |
| HDL-C (mmol/l) | 1.44±0.33 | 1.56±0.44 | 0.03 |
| HMW adiponectin | 2.50±1.90 | 3.26±2.46 | 0.04 |
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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