Endocrine Abstracts

The McCune–Albright syndrome is a rare condition of variable severity that typically presents in childhood and is characterized by the triad of fibrous dysplasia (FDP), endocrinopathy and café-au-lait spots. The syndrome was independently described by Donovan McCune (1902–1976) and Fuller Albright (1900–1969) approximately 70 years ago and is now recognized to be the result of post-zygotic somatic constituently activating mutations of the alpha subunit of t...

Fibrous dysplasia (FD) is a focal bone lesion composed of immature mesenchymal osteoblastic precursor cells which may occur at one site (monostotic) or multiple sites (polyostotic) in individual patients. Polyostotic FD may also be associated with other manifestations, including hyperpigmented (café-au-lait) skin lesions, gonadotropin-independent sexual precocity, and/or other endocrine and nonendocrine manifestations, and these constellation of features are known as the ...

Fibrous dysplasia of bone (FD) – a rare disease due to osteoblastic lineage differentiation defects – is associated with bone pain, fracture and bone deformity, but few therapeutic options are available. Antiresorptive agents such as bisphosphonates may be of interest because there is evidence of increased osteoclastic activity in FD bone lesions, even if the disease is due to an osteoblastic defect.We have reviewed published data on the treatm...