Endocrine Abstracts

Bone metabolism can be measured indirectly with specific biochemical markers. Desoxypyridinolin (DPD) is a derivate of hydroxypyridinium, which is discharged by bone resorption and is totally excreted urinary. A further marker of collagen resorption is the c-terminal telopeptide of collagen type I, which is liberated to blood circulation within the bone’s degradation and undergoes renal elimination. The aim of our investigation was to look after a correlation of these parameters in healthy subjects (n=28), patients with type 1 diabetes mellitus (DM) (n=65), and female patients with diagnosed postmenopausal osteoporosis (PMO). For the labaratory analysis of DPD we used a solid phase chemiluminescence enzymimmunoassay and for assessment of c-terminal telopeptide of type I – collagen a quantitative ELISA was used. We found correlations of both parameters within the main group (n=181), and all the other subgroups. The strongest correlation could be found in the group with DM type 1 (r=0.79, P<0.05) followed by the group of healthy subjects (r=0.75, P<0.05). In the group of female patients (PMO) a weaker, but significant positive correlation could be verified (r=0.58, P<0.05). The arithmatic average of DPD was in the group of healthy subjects about 15,4 nM DPD/mM Krea (95%KI: 11.1–19.72), in the group of type 1 DM patients 21.02 (11.23–30.82) and about 38.51 (28.32–48.7) nM DPD/mM Krea in the group of the female patients (PMO). Both parameters reflect the diverse amount of bone turnover and correlated significantly positive to each other. In comparison to the healthy subjects an enhanced bone turnover could be measured consistently in the group of type 1 DM patients. The hihgest values but concurrent the widest statistic spread with weaker correlation was measured in the group of female patients (PMO). This may indicate, that the results found before therapy are of limited diagnostic value, unlike in the course of antiresorptive therapy the observed significant alterations of bone resorption parameters are of specific diagnostic value.