Endocrine Abstracts

Background and aim: Hyperprolactinemia may associate with insulin resistance. This fact has been determined by many studies with methods which show insulin sensitivity. In this study we aimed to search insulin resistance with golden standard euglycemic hyperinsulinemic clamp technique on hyperprolactinemic patients.

Subjects and methods: This study was performed in Endocrinology Department of Dicle University. Sixteen patients with microprolactinoma (mean age: 32.06±11.60 year and BMI: 24.43±3.23 kg/m²) 12 healthy subjects (mean age: 31.25±9.40 year and BMI:24.33±3.42 kg/m²) were included to the study. Fasting glucose, insulin levels and lipid parameters were measured in both groups. HOMA-B and HOMA-IR values of groups were calculated. Euglycemic hyperinsulinemic clamp technique was performed to the both group and M value of the groups was defined. Mann-Whitney U and Chi-Square tests were used in statistically analysis.

Result: Age, BMI, total cholesterol, triglycerides, LDL-cholesterol, HDL-Cholesterol and fasting glucose levels of the groups were not show statistically difference. Basal insulin level of hyperprolactinemic patients were higher than control group (6.85±4.68; 3.66±0.88 pU/ml respectively; P<0.05). Mean HOMA-IR and HOMA-B values of patients were higher than control group (1.49±1.30, 0.78±0.27 respectively; P<0.05) (136.28±72.53, 64.77±23.31 respectively, P<0.05). Insulin resistance was determined on 5 patients by euglycemic hyperinsulinemic clamp technique (M<4). M values of the patients were statistically lower than control group (5.64±2.36, 7.05±1.62 kg/mg/m² respectively, P<0.05).

Conclusions: 1- Hyperprolactinemia is associated with an insulin-resistant state

2- Insulin resistance of hyperprolactinemic patients is not associated with obesity.