ECE2007 Poster Presentations (1) (659 abstracts)
The relationship between the increased body mass index and the bone fracture prevalence in postmenopausal pollen allergic women
Viktoria Ferencz 1 , Szilvia Meszaros 1 , Emoke Csupor 2 , Edit Toth 3 , Katalin Bors 4 , Andras Falus 5 & Csaba Horvath 1
11st Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary; 2The Health Service, Budavar Local Authorities, Budapest, Hungary; 3Department of Reumatology, Flor Ferenc Country Hospital, Kerepestarcsa, Hungary; 4The Health Sevice, Ferencvaros Local Authorities, Budapest, Hungary; 5Department of Genetics, Cell- and Immunobiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Our aim was to investigate whether pollen-allergy can affect fractures in postmenopausal women. A total of 125 postmenopausal pollen-allergic women (mean age 61.26 yr) were split into four groups: treated neither with H1 histamine receptor (H1R) antagonist nor with inhaled corticosteroid (n=43), treated only with H1R antagonist (n=53), treated both with H1R antagonist and inhaled corticosteroid (n=17), treated only with inhaled corticosteroid (n=12) for at least 5 years, seasonally. One hundred non-allergic postmenopausal subjects matched for age, body mass index (BMI) and age at menopause served as controls. Overweight and obesity (25 kg/m2≤BMI) were common among allergic women (76%). Untreated allergic had almost triple the rate of prevalent low-energy fractures (distal forearm, hip and clinical vertebral fractures: 34.9%) compared to non-allergic women (13%, chi2 P=0.003). Bone fracture occurred more often in H1R-only treated patients (30.19%) than in controls (chi2 P=0.01), however, clinical vertebral or hip fractures developed neither in those treated only with H1R antagonist nor in those who received both H1R antagonist and inhaled corticosteroid. Bone fractures were more frequent among patients with inhaled steroid treatment than among patients with a combined treatment of inhaled steroid and antihistamine (50% vs. 29.4%). BMI predicted prevalent fractures at 1.278 (95% CI, 1.047 to 1.559, P=0.016) for 1 kg/m2 increase among untreated allergic patients. In conclusion we found a high prevalence of low-energy fractures among pollen-allergic postmenopausal women, which was associated with obesity. It is possible that the H1R antagonists compensate for the negative effect of pollen-allergy and the adverse effect of inhaled corticosteroid treatment on bone fracture risk.
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Endocrine Abstracts
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