ECE2007 Poster Presentations (1) (659 abstracts)
Evaluation of diastolic function and its relationship with carotis intima media thickness and endothelial function in asymtomatic hyperparathyroid patients
Dilek Yazici 1 , Ozlem Tarcin 1 , Beste Ozben 2 , Ahmet Toprak 2 , Oguzhan Deyneli 1 , Seda Sancak 1 , Dilek Yavuz 1 & Sema Akalin 1
Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.
Twenty six patients with asymptomatic hyperparathyroidism (HP) (23.4±3.9 y; F/M:17/9) and 25 healthy controls (24.4±3.6 y; K/E:18/7) were recruited. Left ventricular mass index (LVMI), isovolumetric relaxation time (IVRT), early (E) and late (A) atrial peak filling velocity were measured by conventional and Doppler echocardiography. Tissue Doppler imaging, a method with better results in determining diastolic dysfunction, was used to determine mitral annular early (E’) and late (A’) peak diastolic filling rate. FMD and CIMT were determined by Doppler echocardiography. The study was approved by the local Ethical Committee.
| ASYMTOMATIC HP (n=26) | CONTROL (n=25) | P | |
| Calcium (mg/dL) | 9.72±0.41 | 9.69±0.76 | NS |
| Phophorus (mg/dL) | 3.98±0.66 | 3.90±0.40 | NS |
| PTH (pg/mL) | 91.53±24.50 | 42.98±10.69 | P<0.0001 |
| FMD (%) | 9.62±3.74 | 9.52±3.13 | NS |
| CIMT (mm) | 0.46±0.05 | 0.47±0.04 | NS |
LVED, LVMI, IVRT, E/A, E’/A’ and E/E’ ratios were comparable between groups. PTH was weakly correlated with CIMT (r=−0.26; P=0.23), but not with echocardiographic parameters and FMD.
Diastolic dysfunction was not observed in asymptomatic hyperparathyroid patients. It is evident from this preliminary data that cardiac manifestations do not start at this stage of disease, but further studies with larger groups are needed to confirm this finding.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more