Endocrine Abstracts

Introduction: In elderly men testosterone and DHEAS deficiency is often observed, also changes of body composition and metabolic disturbances are common disorders.

Objectives: The aim of this study was to analyze the association between testosterone and DHEAS deficiency and waist/hip ratio (WHR) and also levels of glucose, insulin, HOMA and FG/FI ratio in elderly men as well as analysis, whether these sex hormones influent on measured parameters separately.

Material and methods: Together 85 men with age from 60 to 70 years men (mean 66.3±1.5 years) was analyzed. Testosterone levels<4 ng/ml or DHEA levels<2000 ng/ml and BMI<30 kg/m² were including criteria. Patients were divided into three groups: 52 with testosterone deficiency (L-T), 32 with DHEA deficiency (L-DHEA-S) and 67 with deficiency of both sex hormones (L-T/DHEA-S).

Results: Testosterone levels in L-T, L-DHEA and L-T/DHEA groups were respectively 3.19±0.23 ng/ml, 4.89±0.45 ng/ml and 3.25±0.34 g/ml (P<0.002). While DHEA-S levels were respectively: 2498±98 ng/ml, 1435±1010 ng/ml and 1501±89 ng/ml). BMI values do not deferent between groups. WHR ratio values were the highest in L-T/DHEA-S group (P<0.05 vs. L-T) group, significant lower in L-T group (P<0.005 vs. L-DHEA-S) and the lowest in L-DHEA-S group. Insulin fasting levels were lowest in L-DHEA-S group, higher in L-T group (P<0.01) and highest in L-T/DHEA-S group (P<0.001 vs, L-T group). FG/FI values were highest in L-DHEA-S group, lower in L-T group (NS) and lowest in L-T/DHEA group (P<0.002 vs. L-T group). HOMA ratio values similarly did not change significantly between L-T (6.6±3.21) and L-DHEA-S group (5.5±2.92), although tendency to higher values in L-T group was noticed, while WHR ratio values were significant higher in L-T/DHEA group (7.3±2.45; P<0.002 vs. L-T group).

Conclusions: DHEAS and testosterone deficiency were independently associated with higher insulin resistance and obesity and also WHR ratio is more sensitive then BMI ratio reflects androgen deficiency influence on obesity and body composition in elderly men.