ECE2007 Poster Presentations (1) (659 abstracts)
Plasma adiponectin and leptin levels in menopausal metabolic syndrome
David Virsaladze 1 , Nona Adamia 1 , Nino Charkviani 1 , Ketevan Khitarishvili 1 , Tea Giorgadze 1 & David Tananashvili 2
1Tbilisi State medical University, Tbilisi, Georgia; 2E. Andronikashvili Institute of Physics, Tbilisi, Georgia.
Objective: The aim of our investigation was the study of blood adiponectin and leptin levels in patients with menopausal metabolic syndrome (MMS) and their correlation with the parameters of MMS features.
Methods: 40 females with menopausa have been investigated. In 38 cases diabetes mellitus type 2 has been registered, and in 2 – impaired glucose tolerance. Mean duration of postmenopausal period was 11.1±7.4. Control group consisted of 10 females of postmenopusal age. The blood content of adiponectin and leptin was measured by ELISA. For MMS diagnostics WHO classification (2002) was applied.
Results: In basic group MMS was revealed in 37 patients, in control group – in 3 cases (χ2=19.53, P<0,001). It was not observed significant difference in blood adiponectin levels of basic and control groups (16.4±7.6 vs. 16.3±6.1, P=NS), but blood leptin level was significantly higher in investigated group in comparison with control (166.7±105.3 vs. 60.3±51.0, P<0.001). It was revealed significant correlations of blood adiponectin and leptin levels with the parameters of MMS features.
Conclusions: Obtained results show that blood adiponectin level in MMS does not differed from control value. Blood leptin level is significantly higher than control one. They significantly correlated with the parameters of MMS features.
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Endocrine Abstracts
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