Endocrine Abstracts

Metabolic syndrome (MS) represents a prominent risk factor for cardiovascular disease. Parameters of MS were compared between obese women and controls. I: 50 women (31.92±5.83 kg/m²; 54.4±3.64 y’s); Controls: 37 women (23.50±2.13 kg/m²; 53.92±3.95 y’s). Weight, height, waist and hips circumference, sagital abdominal diameter (SAD) and blood pressure (BP) were measured. Blood was taken at 8 am for: fasting glucose, triglycerides, cholesterol, HDL, LD, Lp(a), FSH, LH, PRL, E2 and OGTT was performed. Hormone analyses: RIA. Statistics: T test, Mann – Whitney U test, ANOVA. MS: 66% in I and 22% in controls. Significant differences between groups were found for: glycose (6.22±2.26 vs 5.49±2.43 mmol/l, P<0.05), weight (86.20±17.82 vs 62.81±7.90 kg, P<0.01), waist (99.96±14.65 vs 79.9±8.78 cm, P<0.01), hips circumference (114.31±11 vs 96.93±11.04 cm, P<0.01), SAD (31.9±6.83 vs 24.9±9.86 cm, P<0.01), BMI (31.92±5.83 vs 23.5±2.13 kg/m², P<0.01), diastolic BP (93.08±13.41 vs 85.75±10.54 mmHg, P<0.01), Lp(a) (0.50±0.36 vs 0.11±0.03 g/l, P<0.01), FSH (54.35±27.16 vs 72.32±30.17 IU/L, P<0.01), LH (20.33±11.08 vs 28.77±14.16 IU/L, P<0.01), PRL (251.52±142.60 vs 370.27±237.74 nmol/l, P<0.05). There are positive correlations between menopausal duration and waist, BMI and BP. Negative correlation was found for BMI, menopausal duration and HDL.

Conclusion: Hypoestrogenic status in the menopausal women shows a shift to a central android fat distribution and MS that can be counteracted by HRT.