Gastroenteropancreatic endocrine tumors

In the gastroentero-pancreatic tract, a spectrum of neuroendocrine tumors (NET) exists, including low grade tumors (carcinoid), intermediate grade malignant carcinoid, and high grade poorly differentiated carcinomas of the small and large cell types. In year 2000, the WHO presented a classification scheme for all NETs, but mostly applied to gastroentero-pancreatic tumors. This term carcinoid was replaced by (neuro)endocrine tumor, malignant carcinoid by well differentiated (ne...

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ea0014s4.2 | Gastroenteropancreatic endocrine tumors | ECE2007

Biological, morphological work-up and screening for inherited disease

Skogseid Britt

Pancreatic endocrine tumors (EPT) may occur sporadically or in association with the rare autosomal dominantly inherited tumor syndromes; multiple endocrine neoplasia type 1 (MEN1) and von Hipple Lindau (VHL). The genes causing these syndromes have been identified, and genotyping is possible which enables the laborious clinical investigations for diagnosis of lesions to be restricted to 50% of family members. For MEN1, no clinically useful genotype-phenotype correlation as been...

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ea0014s4.3 | Gastroenteropancreatic endocrine tumors | ECE2007