Endocrine Abstracts

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The pro-inflammatory cytokine interleukin-1 is selectively cytotoxic to rodent and human beta-cells in vitro, and anti-IL-1 therapies reduce diabetes incidence in animal prevention models: (1) IL-1 alone or in combination with other inflammatory cytokines causes beta-cell destruction in rodent and human islets and in perfused pancreas via MAPK and NFkB signaling, (2) IL-1 given i.p. to non-diabetes prone animals causes transient insulinopenic diabetes (3) IL-1 is expres...

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Stem cells are clonogenic cells capable of both self-renewal and multilineage differentiation. Therefore, these cells have the potential to proliferate and differentiate into any type of cell and to be genetically modified ‘in vitro’, thus providing cells which can be isolated and used for transplantation. Moreover, these derived cells have proven to be useful in different animal models. Using a combination of several directed differentiation methods (nicotina...