Ghrelin levels in lean patients with polycistic ovary syndrome

Maja Georgiev; Dragan Micic; Mirjana Sumarac-Dumanovic; Aleksandra Kendereski; Danica Stamenkovic-Pejkovic; Goran Cvijovic; Svetlana Zoric; Nebojsa Zecevic

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Endocrine Abstracts (2007) 14 P653

ECE2007 Poster Presentations (1) (659 abstracts)

Ghrelin levels in lean patients with polycistic ovary syndrome

Maja Georgiev ¹ , Dragan Micic ¹ , Mirjana Sumarac-Dumanovic ¹ , Aleksandra Kendereski ¹ , Danica Stamenkovic-Pejkovic ¹ , Goran Cvijovic ¹ , Svetlana Zoric ¹ & Nebojsa Zecevic ²

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¹Institute of endocrinology, diabetes and diseases of metabolism, Belgrade, Serbia; ²Clinic for Gynecology and Obstetric NARODNI FRONT, Belgrade, Serbia.

It was speculated that androgen levels and insulin resistance may have influence on ghrelin levels. Elevated, normal and low ghrelin levels were reported in women with polycystic ovary syndrome (PCOS). The aim of our study was to investigate the basal ghrelin levels in lean patients with PCOS and to evaluate possible correlations between ghrelin levels, insulin resistance and, androgen levels. In 10 lean PCOS patients (BMI 20.45±0.51 kg/m², age: 21.4±0.85 years) and 8 lean controls (BMI 20.92±0.69 kg/m², age: 25.37±2.41 years) basal ghrelin (RIA, Linco, USA, pg/ml) and testosteron (RIA, INEP, nmol/l) levels were determinated. Insulin sensitivity was determinated using euglycemic hyperinsulinemic clamp (M index).

Results: There was significant difference in ghrelin levels (51.82±26.83 vs 120.11±58.42, P<0.05) and M index values (3.68±0.66 vs 7.84±1.28, P< 0.05) between PCOS patients and controls. There were no significant correlations between ghrelin and testosterone (r=0.40, P<0.05), as well between ghrelin and M index values (r=−0.12, P>0.05). In conclusion, we observed lower lower ghrelin levels in lean PCOS patients than in camparative controls. Insulin resistance might have influence on low ghrelin levels in this group of patients.