Insulin levels and lipid profile in lean women with polycystic ovary syndrome

Mirjana Stojkovic; Milos Zarkovic; Jasmina Ciric; Biljana Beleslin; Slavica Savic; Djordje Marina; Bozo Trbojevic; Milka Drezgic

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Endocrine Abstracts (2007) 14 P649

ECE2007 Poster Presentations (1) (659 abstracts)

Insulin levels and lipid profile in lean women with polycystic ovary syndrome

Mirjana Stojkovic , Milos Zarkovic , Jasmina Ciric , Biljana Beleslin , Slavica Savic , Djordje Marina , Bozo Trbojevic & Milka Drezgic

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Institute of endocrinology, Belgrade, Serbia.

Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Insulin resistance is one of the features of PCOS and potentially affect lipid metabolism.

Objectives: The aim of this study was to compare basal insulin levels and lipid profile in lean women with PCOS with weight matched healthy controls.

Methods: The study group consisted of 64 women divided in two subgroups (1. PCOS group, n=48; age 25.7±6.2; BMI 21.3±1.9 kg/m². 2. group of healthy controls, n=16, age 26.8±6.4; BMI 20.3±1.6 kg/m²). Data were analyzed by the t test.

Results: Mean basal glucose levels were 4.38±0.46 mmol/L vs. 4.54±0.23 mmol/L, without statistically significant difference between groups. Mean basal insulin levels were significantly higher in PCOS group than in healthy controls (24.82±16.34 mIU/L vs. 6.47±3.19 mIU/L; P=0,001;). Cholesterol, HDL and LDL cholesterol levels did not reach statistically significant difference between groups, while triglyceride levels were significantly higher in PCOS group than in healthy controls (1.05±0.44 mmol/L vs. 0.73±0.22; P=0,009;).

Conclusions: These data suggest that PCOS per se, without obesity, affects insulin secretion and lipid metabolism, mainly in triglyceride levels which enhances atherogenic potential in this subjects.