ECE2007 Poster Presentations (1) (659 abstracts)
Validation of different insulin sensitivity indices in GH deficiency children using roc curve analysis
R Baldelli 1 , S Bellone 2 , G Corneli 2 , A Giampietro 3 , V Cimino 3 , A Pontecorvi 3 , L De Marinis 3 & G Bona 2
1Regina Elena Cancer Institute, Rome, Italy; 2University of Piemonte Orientale, Rome, Italy; 3Catholic University of Sacred Hearth, Rome, Italy.
Insulin sensitivity in GHD patients tends to decrease with age and variations in body composition. Several indices of insulin sensitivity have been considered and among these HOMA, ISI and QUICKI are based on mathematical calculations taking into account glucose and/or insulin levels either in basal conditions or after OGTT. Aim of present study was to validate the different indices in a population of pre-pubertal GHD children (n=66) by ROC curve analysis. All patients underwent OGTT with evaluation of glucose and insulin. To validate the different indices the ROC curve analysis has been used with the aim to provide the cut-off limit, sensitivity and specificity for each index. The lowest limit of normality was defined as the value that provided the best pair of highest sensitivity/specificity for HOMA, ISI and QUICKI. Evaluating data derived from ROC curve analysis we have found that ISI index was the most robust index of insulin sensitivity. Using a cut-off of 0.6, HOMA shows a sensitivity of 29% and a specificity of 83.7%; using a cut-off of 0.4, QUICKI shows a sensitivity of 32.3% and a specificity of 88.4%; using a cut-off of 9.2, ISI shows a sensitivity of 43.5% and a specificity of 100%. Applying the cut-off point for ISI, among the patients we found that 42% of GHD children were insulin resistant. This kind of diagnosis was difficult before, because the specific cut-off limits of ISI had not been calculated. Data from the current study demonstrate that ISI was more potent respect to HOMA and QUICKI and represent a convenient test for the diagnosis of insulin resistance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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