ECE2007 Poster Presentations (1) (659 abstracts)
Structured assessment of neuroendocrine dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage – the interdisciplinary German database
Ilonka Kreitschmann-Andermahr 1 , Harald Schneider 2 , Michael Buchfelder 3 , Bernhard Saller 4 , Eberhard Koenig 5 , Martina Jordan 1 & Günter Stalla 2
1RWTH Aachen University, Aachen, Germany; 2Max-Planck-Institute for Psychiatry, Internal Medicine/Endocrinology and Clinical Chemistry, Munich, Germany; 3Erlangen University, Erlangen, Germany; 4Endoscience GmbH, Munich, Germany; 5Neurological Rehabilitation Clinic, Bad Aibling, Germany, ClinSupport GmbH, Erlangen, Germany.
The results of recent studies indicate that traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) must be considered as frequent causes of long-term disturbances of hypothalamo-pituitary function. Indeed, partial hypopituitarism has been established with a pooled frequency of 33% in TBI and of 48% in SAH survivors. Nevertheless, still little is known about risk factors and clinical characteristics of pituitary impairment after these two types of brain damage.
In order to address these questions on a larger scale, a multi-center, structured data assessment to create a national registry of these patients has been established in 2005. It is coordinated by an endocrinological department in the south of Germany and is financed by an independent investigator grant. At present, 10 active neurosurgical, rehabilitation and endocrinological centers in all of Germany participate in the database. Ethical committee approval has been obtained for the project. Data are collected using a structured, internet-based study sheet, obtaining information on clinical, radiological and hormonal parameters. The database aims to connect clinical information on trauma and presence and type of hypopituitarism. At the first data close, which is due in November 2006 more than 500 patients with TBI (n=322) or SAH (n=178) have been included of whom clinical data and basal hormone values are available. In 112 TBI patients (34.8%) and 46 SAH patients (25.4%) additional endocrine function testing has been performed. This conference contribution aims to present the scientific results of the first data close and to introduce this epidemiological tool which is open to all disciplines treating patients with brain injury in Germany to the European scientific community. The authors present this database on behalf of all participating centers.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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