Endocrine Abstracts

Differentiated thyroid carcinomas (DTC) (papillary, follicular and follicular type of papillary) are characterized by a favourable prognosis, but a part of patients can develop recurrences and eventually die of the disease. We retrospectively reviewed 108 DTC patients affected by locally advanced thyroid carcinoma (77 females, 31 males) (49±15 years), in order to evaluate validate known prognostic factors that enable them to be recognised as having a low or a high risk of death related to the tumor, by reference to the staging classifications systems. The TNM classification was as followed: T2b (0.9%), T3 (62%), T3b (30%), T4a (5.5%), T4B (1.8%). The mean diameter of tumor was 24±1 mm. In particular the histology was papillary (62%), follicular (8%), follicular type of papillary (28%), Hurtle (1%), Hurtle+papillary (1%). Lymph nodes status was N0 (9.2%), N1a (13.8%), N1b (26.8%), Nx (50%) while metastases were present in 3.7% of patients. With the regards of stage patients were stage I (50%), stage III (33.3%), stage 4a (12%), stage IV b (3.7%). Seven of them (6.4%) had local or distant recurrences. Thyroiditis was found in 30% at the histology. No deaths were reported regarding our group of patients. Papillary and follicular thyroid carcinoma, referred to as differentiated thyroid carcinoma (DTC) cover the majority of thyroid carcinoma cases. The prognosis for DTC is usually excellent, but even so a proportion of the patients develop recurrences and eventually die of the disease. In particular the majority of our patients (50%) were in the stage I explaining the good prognosis of this group of patients. These previous data show that age at the time of diagnosis, histological type, tumour size and extrathyroidal invasion are associated with a good clinical outcome.