ECE2007 Poster Presentations (1) (659 abstracts)
The changes in the incidence of nodular goitre, thyroid cancer and urine excretion of iodine in the inhabitants of north eastern Poland in 1997 and 2005
Anna Zonenberg 1 , Wieslaw Zarzycki 1 , Beata Telejko 1 , Anna Modzelewska 1 , Agnieszka Nikolajuk 1 , Mikolaj Rybaczuk 2 , Janusz Dzieciol 3 , Katarzyna Siewko 1 , Ida Kinalska 1 & Maria Gorska 1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Bialystok, Poland; 2Department of Business, &br;Informatics and Logistics, Technical University, Bialystok, Poland; 3Department of Human Anatomy, Medical University, Bialystok, Poland.
A higher incidence of nodular goitre and less differentiated types of thyroid carcinoma have been observed in iodine deficient regions. North-Eastern Poland was an area with a moderate deficiency of iodine until the introduction of the mandatory salt iodination in 1997 (30±10 mg KJ/kg NaCl). The aim of our study was to compare the incidence of goitre, thyroid carcinoma and urine excretion of iodine in the inhabitants of the North-Eastern Region of Poland in 1997 and 2005. In 1997 816 persons were investigated, 431 (52.8%) of whom reported for follow-up investigation in 2005. The study consisted of a questionnaire. thyroid ultrasonography and the measurement of iodine concentration in random urine sample. Parenchymatous goitre was found in 267 persons (32.7%) in 1997 and in 37 persons (8.6%) in 2005 (P<0.001. chi2-58.165). The incidence of nodular goitre was 12.75% (104 persons) and 24.59% (106 persons), respectively (P<0.001. chi2-19.557). In 1997 three cases of papillary carcinoma were diagnosed. and in 2005 – 1 case. Decreased iodine excretion was observed in 71.28% subjects in 1997 and in 19.1% in 2005 (P<0.001. chi2-105.748). Conclusion. During the last 8 years, the incidence of parenchymatous goitre in the North–Eastern Poland significantly decreased, whereas the percentage of nodular goitre increased in the period analysed. Prospective analysis did not reveal an increase in thyroid carcinoma incidence. The observed changes may be due to the introduction of the mandatory iodination of table salt in Poland in 1997.
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Endocrine Abstracts
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