Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P262

ECE2007 Poster Presentations (1) (659 abstracts)

Body composition and GH status in morbidly obese females before and after laparoscopic silicone adjustable-gastric banding

Silvia Savastano 1 , Annamaria Colao 1 , Francesca Rota 1 , Laura Vuolo 1 , Maria Cristina Savanelli 1 , Teresa Cascella 1 , Francesco Orio 1 , Luigi Angrisani 2 , Gaetano Lombardi 1 & Carolina Di Somma 1


1Department of Molecular and Clinical Endocrinology, Federico II University, Naples, Italy; 2Department of Surgery, S.Giovanni Bosco Hospital ASL NA1, Naples, Italy.


The GH/IGF-I axis function are reported to ameliorate after weight-loss. Bariatric surgery leads to a significant weight loss in morbidly obese patients. We investigated the relationships between GH/IGF-I axis and body composition in 20 morbidly obese females (BMI: 44.8±4.7; waist circumference (W) 119.5±7.2 cm, age 33.7±11.7 yrs) with a normal glucose tolerance, before and after laparoscopic silicone adjustable-gastric banding (LASGB). The GH axis was evaluated by GH response after GHRH+arginine test and IGF-I levels. Patients were evaluated 6 months after surgery and a well balanced mildly hypocaloric diet. Fat Mass (FM), Free Fat Mass (FFM) were evaluated by bioimpedance analysis. Before surgery, 8 (40%) subjects were GH deficient (peak GH<4.2 μg/l), while 7 (35%) had IGF-I levels below the normal values for age and sex. Postoperatively, GH response was persistently impaired in 3 (15%) subjects, while IGF-I levels were still reduced in 9 (45%). After 6 months BMI, W, FM (P<0.001) and FFM (P=0.03) were significantly reduced. The percent decrement of FM was greater than that of FFM (22.4±16% vs 5.6±2.3%; P<0.001). GH response was persistently impaired in 3 (15%) subjects, while IGF-I levels were still reduced in 9 (45%). In addition, a significant correlation was found between the decrement of FFM (r=0.81; P<0.001) and that of FM (r=0.47; P<0.04) and the decrement of IGF-I. At the multiple regression analysis, the percentage of FM and W at baseline were the major determinants of IGF-I. In conclusion, both the nutritional status and a relative malabsorption might affect IGF-I and FFM. After bariatric surgery and after the initial acute negative energy balance, a persistent deficiency in GH/IGF-I axis is present and this particular endocrine profile is also associated to unfavourable body composition changes. The low IGF-I levels might represent a possible marker of an underlying persistent catabolic state in these subjects.

Article tools

My recent searches

No recent searches.