ECE2007 Poster Presentations (1) (659 abstracts)
Pioglitazone modifies the effects of growth hormone on lipolysis and insulin sensitivity
Morten B Krag 1 , Søren Nielsen 1 , ZengKui Guo 2 , Steen B Pedersen 3 , Ole Schmitz 1 , Jens S Christiansen 1 & Jens OL Jørgensen 1
1Medical Department M, Aarhus University Hospital, DK-8000 Aarhus C, Denmark; 2Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, United States; 3Medical Department C, Aarhus University Hospital, DK-8000 Aarhus C, Denmark.
Context: Thiazolidiones (TZD) improves insulin sensitivity in type 2 diabetes via effects on fat metabolism, whereas growth hormone (GH) stimulates lipolysis and induces insulin resistance.
Objective: To evaluate the effects of TZD on fat metabolism and insulin sensitivity in GH-treated GH deficient (GHD) patients.
Design: Randomized, placebo-controlled, double-blind parallel-group study including 20 GHD patients on continued GH replacement therapy. The patients were studied before and after 12 weeks.
Intervention: Patients received either tablet pioglitazone 30 mg (N=10) or placebo (N=10) once daily for 12 weeks.
Results: 12 weeks of pioglitazone treatment in GH-replaced GHD patients was associated with improved insulin sensitivity (P=0.03) and increased basal glucose oxidation (P=0.004). Change in insulin-stimulated adiponectin level after pioglitazone treatment was positive correlated to the change in insulin-stimulated total glucose disposal (R=0.69, P=0.04). Pioglitazone significantly decreased basal free fatty acid levels (P=0.02) and lipid oxidation (P=0.02). Adiponectin levels almost doubled during pioglitazone treatment (P=0.0001).
Conclusion: The impact of GH on lipolysis and insulin sensitivity is modified by administration of PPARγ agonists.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more